Auflistung nach Schlagwort "Binding Sites"

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  • Binding of a Pyrene-Based Fluorescent Amyloid Ligand to Transthyretin: A Combined Crystallographic and Molecular Dynamics Study 
    Thi Minh, Nghia Nguyen; Begum, Afshan; Zhang, Jun; Leira, Petter; Todarwal, Yogesh; Linares, Mathieu; Norman, Patrick; Derbyshire, Dean; von Castelmur, Eleonore; Lindgren, Mikael; Hammarström, Per; König, Carolin (Washington, DC : Soc., 2023)
    Misfolding and aggregation of transthyretin (TTR) cause several amyloid diseases. Besides being an amyloidogenic protein, TTR has an affinity for bicyclic small-molecule ligands in its thyroxine (T4) binding site. One class ...
  • Human embryonic stem cell-derived test systems for developmental neurotoxicity: A transcriptomics approach 
    Krug, Anne K.; Kolde, Raivo; Gaspar, John A.; Rempel, Eugen; Balmer, Nina V.; Meganathan, Kesavan; Vojnits, Kinga; Baquié, Mathurin; Waldmann, Tanja; Ensenat-Waser, Roberto; Jagtap, Smita; Evans, Richard M.; Julien, Stephanie; Peterson, Hedi; Zagoura, Dimitra; Kadereit, Suzanne; Gerhard, Daniel; Sotiriadou, Isaia; Heke, Michael; Natarajan, Karthick; Henry, Margit; Winkler, Johannes; Marchan, Rosemarie; Stoppini, Luc; Bosgra, Sieto; Westerhout, Joost; Verwei, Miriam; Vilo, Jaak; Kortenkamp, Andreas; Hescheler, Jürgen; Hothorn, Ludwig A.; Bremer, Susanne; van Thriel, Christoph; Krause, Karl-Heinz; Hengstler, Jan G.; Rahnenführer, Jörg; Leist, Marcel; Sachinidis, Agapios (Heidelberg : Springer Verlag, 2013)
    Developmental neurotoxicity (DNT) and many forms of reproductive toxicity (RT) often manifest themselves in functional deficits that are not necessarily based on cell death, but rather on minor changes relating to cell ...
  • L-amino acid oxidases with specificity for basic L-amino acids in cyanobacteria 
    Gau, Achim E.; Heindl, Achim; Nodop, Anke; Kahmann, Uwe; Pistorius, Elfriede K. (Berlin : De Gruyter, 2007)
    The two closely related fresh water cyanobacteria Synechococcus elongatus PCC 6301 and Synechococcus elongatus PCC 7942 have previously been shown to constitutively express a FAD-containing L-amino acid oxidase with high ...
  • The periplasmic transaminase PtaA of Pseudomonas fluorescens converts the glutamic acid residue at the pyoverdine fluorophore to -ketoglutaric acid 
    Ringel, Michael T.; Dräger, Gerald; Brüser, Thomas (Bethesda, Md. : ASBMB Publications, 2020)
    The periplasmic conversion of ferribactin to pyoverdine is essential for siderophore biogenesis in fluorescent pseudomonads, such as pathogenic Pseudomonas aeruginosa or plant growth-promoting Pseudomonas fluorescens. The ...
  • Proteolytic release of the intramolecular chaperone domain confers processivity to endosialidase F 
    Schwarzer, David; Stummeyer, Katharina; Haselhorst, Thomas; Freiberger, Friedrich; Rode, Bastian; Grove, Melanie; Scheper, Thomas; Itzstein, Mark von; Mühlenhoff, Martina; Gerardy-Schahn, Rita (Bethesda, Md. : ASBMB Publications, 2009)
    Endosialidases (endoNs), as identified so far, are tailspike proteins of bacteriophages that specifically bind and degrade the α2,8-linked polysialic acid (polySia) capsules of their hosts. The crystal structure solved for ...
  • Stable Insertion of the Early Light-induced Proteins into Etioplast Membranes Requires Chlorophyll a 
    Adamska, Iwona; Kruse, Elisabeth; Kloppstech, Klaus (Bethesda, Md. : ASBMB Publications, 2000)
    Etiolated plant seedlings exposed to light respond by transient accumulation of the nucleus-encoded, plastid-located early light-inducible proteins (Elips). These proteins are distant relatives of the light-harvesting ...
  • Studies with lysine N6-hydroxylase. Effect of a mutation in the assumed FAD binding site on coenzyme affinities and on lysine hydroxylating activity 
    Stehr, Matthias; Smau, Liliana; Singh, Mahavir; Seth, Oliver; Macheroux, Peter; Ghisla, Sandro; Diekmann, Hans (Berlin : De Gruyter, 1999)
    The proposed FAD binding site of L-lysine N6-hydroxylase (EC 1.14.13.99) exhibits an unusual proline in a position where a highly conserved glycine is found in other FAD dependent hydroxylases. We have studied the role of ...